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The first (classical) pathway is as follows: under normal conditions Nrf2 is localized in cytoplasm and associated with its inhibitor KEAP1 (Kelch-like ECH (Nrf2)-associated protein-1), which stimulates Nrf2 ubiquitinylation and its subsequent proteasomal degradation

Volpedo et al., 2019)

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[71] 2014 season [edit] Hopkins returned as a starting wide receiver alongside Andre Johnson under new head coach Bill O'Brien to begin the 2014 season